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Trans-acting genetic variants causing multilocus imprinting disturbance (MLID): common mechanisms and consequences

16 Mar 2022

Abstract excerpt

BACKGROUND: Imprinting disorders are a group of congenital diseases which are characterized by molecular alterations affecting differentially methylated regions (DMRs). To date, at least twelve imprinting disorders have been defined with overlapping but variable clinical features including growth and metabolic disturbances, cognitive dysfunction, abdominal wall defects and asymmetry. In general, a single specific...

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Share to Epigenetics and DNA Methylation
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PMID: 35296332
DOI: 10.1186/s13148-022-01259-x

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