Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate

15 Mar 2022

Abstract excerpt

Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate hearing and balance disorders. We previously established the benefits of Anc80L65 in targeting inner and outer hair cells in newborn mice. To accelerate translation to humans, we now report the feasibility and efficiency of the surgical approach and vector delivery in a nonhuman primate model. Five rhesus macaques were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hearing, Cochlea, Tinnitus, Genetics
Share to Herpesvirus Infections and Treatments

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35292639
DOI: 10.1038/s41467-022-28969-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primatePMID 35292639Read ↗

Adeno-associated viral vector administration to the inner ear and phenotype evaluation in a mouse model of hearing loss.Semantic proximity Read ↗

Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochleaSemantic proximity Read ↗

Inner Ear Gene Transfection in Neonatal Mice Using Adeno-Associated Viral Vector: A Comparison of Two ApproachesSemantic proximity Read ↗

<i>In vivo</i> -directed evolution identifies AAV-WM04 as a next-generation vector for potent and durable hearing restoration in DFNB9Semantic proximity Read ↗

Cochlear transduction via cerebrospinal fluid delivery of AAV in non-human primatesSemantic proximity Read ↗

Dual-AAV delivery of large gene sequences to the inner earSemantic proximity Read ↗

Gene therapy for hereditary hearing loss.Semantic proximity Read ↗

Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and non-human primatesSemantic proximity Read ↗

<i>In utero</i> adeno-associated virus (AAV)-mediated gene delivery targeting sensory and supporting cells in the embryonic mouse inner earSemantic proximity Read ↗

In Vivo Delivery of Recombinant Viruses to the Fetal Murine Cochlea: Transduction Characteristics and Long-Term Effects on Auditory FunctionSemantic proximity Read ↗

AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial.Semantic proximity Read ↗

Gene Expression in the Mammalian Cochlea: A Study of Multiple Vector SystemsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.