Article
CD24 is a surrogate for 'immune-cold' phenotype in aggressive large B-cell lymphoma.
The journal of pathology. Clinical research - 1 Jul 2022
Higashi Morihiro, Momose Shuji, Takayanagi Natsuko, Tanaka Yuka, Anan Tomoe, Yamashita Takahisa, Kikuchi Jun, Tokuhira Michihide, Kizaki Masahiro, Tamaru Jun-Ichi
Abstract excerpt
The tumor microenvironment (TME) is a critical regulator of the development of malignant lymphoma. Therapeutics targeting the TME, especially immune checkpoint molecules, are changing the treatment strategy for lymphoma. However, the overall response to these therapeutics for diffuse large B-cell lymphoma (DLBCL) is modest and new targets of immunotherapy are needed. To find critical immune checkpoint molecules...
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