Article
Four-Year Disease-Free Remission in a Patient With POLE Mutation-Associated Colorectal Cancer Treated Using Anti-PD-1 Therapy.
Journal of the National Comprehensive Cancer Network : JNCCN - 1 Mar 2022
Durando Michael L, Menghani Sanjay V, Baumann Jessica L, Robles Danny G, Day Tovah A, Vaziri Cyrus, Scott Aaron J
Abstract excerpt
The stability of the human genome depends upon a delicate balance between replication by high- and low-fidelity DNA polymerases. Aberrant replication by error-prone polymerases or loss of function of high-fidelity polymerases predisposes to genetic instability and, in turn, cancer. DNA polymerase epsilon (Pol ε) is a high-fidelity, processive polymerase that is responsible for the majority of leading strand...
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