Article
FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing.
Journal of clinical pathology - 1 Aug 2023
Richman Susan D, Hemmings Gemma, Roberts Helen, Gallop Niall, Dodds Rachel, Wilkinson Lyndsay, Davis Jonathan, White Rhian, Yates Emma, Jasani Bharat, Brown Louise, Maughan Tim S, Butler Rachel, Quirke Philip, Adams Richard
Abstract excerpt
AIMS: FOCUS4 was a phase II/III umbrella trial, recruiting patients with advanced or metastatic colorectal cancer, between 2014 and 2020. Molecular profiling of patients' formalin-fixed, paraffin-embedded tumour blocks was undertaken at two centralised biomarker laboratories (Leeds and Cardiff), and the results fed directly to the Medical Research Council Clinical Trials Unit, and used for subsequent...
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