mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant.

doi:10.1016/j.xcrm.2022.100529

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Article

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant.

Cell reports. Medicine - 15 Feb 2022

Edara Venkata-Viswanadh, Manning Kelly E, Ellis Madison, Lai Lilin, Moore Kathryn M, Foster Stephanie L, Floyd Katharine, Davis-Gardner Meredith E, Mantus Grace, Nyhoff Lindsay E, Bechnak Sarah, Alaaeddine Ghina, Naji Amal, Samaha Hady, Lee Matthew, Bristow Laurel, Gagne Matthew, Roberts-Torres Jesmine, Henry Amy R, Godbole Sucheta, Grakoui Arash, Saxton Marybeth, Piantadosi Anne, Waggoner Jesse J, Douek Daniel C, Rouphael Nadine, Wrammert Jens, Suthar Mehul S

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant emerged in November 2021 and consists of several mutations within the spike. We use serum from mRNA-vaccinated individuals to measure neutralization activity against omicron in a live-virus assay. At 2-4 weeks after a primary series of vaccinations, we observe a 30-fold reduction in neutralizing activity against omicron. Six months...

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Identifiers

PMID: 35233550
DOI: 10.1016/j.xcrm.2022.100529
PMCID: PMC8784612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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