Article
Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera.
Science (New York, N.Y.) - 11 Feb 2022
Muik Alexander, Lui Bonny Gaby, Wallisch Ann-Kathrin, Bacher Maren, Mühl Julia, Reinholz Jonas, Ozhelvaci Orkun, Beckmann Nina, Güimil Garcia Ramón de la Caridad, Poran Asaf, Shpyro Svetlana, Finlayson Andrew, Cai Hui, Yang Qi, Swanson Kena A, Türeci Özlem, Şahin Uğur
Abstract excerpt
The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number of mutations, especially in the spike protein, indicating that recognition by neutralizing antibodies may be compromised. We tested Wuhan (Wuhan-Hu-1 reference strain), Beta (B.1.351), Delta (B.1.617.2), or Omicron pseudoviruses with sera of 51 participants who received...
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