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Article

Proteomic profiling identifies novel proteins for genetic risk of severe COVID-19: the Atherosclerosis Risk in Communities Study.

Human molecular genetics - 21 Jul 2022

Steffen Brian T, Pankow James S, Lutsey Pamela L, Demmer Ryan T, Misialek Jeffrey R, Guan Weihua, Cowan Logan T, Coresh Josef, Norby Faye L, Tang Weihong

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified six genetic variants associated with severe COVID-19, yet the mechanisms through which they may affect disease remains unclear. We investigated proteomic signatures related to COVID-19 risk variants rs657152 (ABO), rs10735079 (OAS1/OAS2/OAS3), rs2109069 (DPP9), rs74956615 (TYK2), rs2236757 (IFNAR2) and (SLC6A20/LZTFL1/CCR9/FYCO1/CXCR6/XCR1) as...

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Topics

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COVID-19
ABO gene
OAS1 gene
TYK2 gene
Genetic Predisposition to Disease
Genome-Wide Association Study
Proteomics
Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 35212764
DOI: 10.1093/hmg/ddac024
PMCID: PMC9307314

Genes

ABO
TYK2
CCR9
CXCR6
DPP9
FYCO1
IFNAR2
LZTFL1
OAS1
OAS2
OAS3
SLC6A20
XCR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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