Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery.

doi:10.1038/s41467-025-61625-0

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Article

Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery.

Nature communications - 10 Jul 2025

Watkins W Scott, Hernandez Edgar J, Miller Thomas A, Blue Nathan R, Zimmerman Raquel Mae, Griffiths Eric R, Frise Erwin, Bernstein Daniel, Boskovski Marko T, Brueckner Martina, Chung Wendy K, Gaynor J William, Gelb Bruce D, Goldmuntz Elizabeth, Gruber Peter J, Newburger Jane W, Roberts Amy E, Morton Sarah U, Mayer John E, Seidman Christine E, Seidman Jonathan G, Shen Yufeng, Wagner Michael, Yost H Joseph, Yandell Mark, Tristani-Firouzi Martin

Abstract excerpt

While exome and whole genome sequencing have transformed medicine by elucidating the genetic underpinnings of both rare and common complex disorders, its utility to predict clinical outcomes remains understudied. Here, we use artificial intelligence (AI) technologies to explore the predictive value of whole exome sequencing in forecasting clinical outcomes following surgery for congenital heart defects (CHD). We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40640177
DOI: 10.1038/s41467-025-61625-0
PMCID: PMC12246213

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