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A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell

22 Feb 2022

Abstract excerpt

Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell's physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of those proteins into the erythrocyte. To reach the host cell, the PEXEL motif of exported proteins is processed by the endoplasmic reticulum (ER) resident aspartyl protease...

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PMID: 35192672
DOI: 10.1371/journal.ppat.1009977

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