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Ferritin-Nanocaged ATP Traverses the Blood–Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model

15 Feb 2022

Abstract excerpt

asthenozoospermia treatment has not been investigated yet. Inspired by the recent advances in nanomedicine, we investigated whether the capability of drug delivery nanocarriers to traverse the blood-testis barrier (BTB) can facilitate ATP-dependent asthenozoospermia treatment. We found that the human H-ferritin (HFn) nanocarrier possesses the capability to traverse the BTB and specifically targets the head of...

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PMID: 35167250
DOI: 10.1021/acsnano.1c10029

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