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Type III CRISPR-based RNA editing for programmable control of SARS-CoV-2 and human coronaviruses

31 Jan 2022

Abstract excerpt

Gene-editing technologies, including the widespread usage of CRISPR endonucleases, have the potential for clinical treatments of various human diseases. Due to the rapid mutations of SARS-CoV-2, specific and effective prevention and treatment by CRISPR toolkits for coronavirus disease 2019 (COVID-19) are urgently needed to control the current pandemic spread. Here, we designed Type III CRISPR endonuclease...

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PMID: 35166837
DOI: 10.1093/nar/gkac016

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