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Article

Rare Hereditary Gynecological Cancer Syndromes.

International journal of molecular sciences - 29 Jan 2022

Watanabe Takafumi, Soeda Shu, Endo Yuta, Okabe Chikako, Sato Tetsu, Kamo Norihito, Ueda Makiko, Kojima Manabu, Furukawa Shigenori, Nishigori Hidekazu, Takahashi Toshifumi, Fujimori Keiya

Abstract excerpt

Hereditary cancer syndromes, which are characterized by onset at an early age and an increased risk of developing certain tumors, are caused by germline pathogenic variants in tumor suppressor genes and are mostly inherited in an autosomal dominant manner. Therefore, hereditary cancer syndromes have been used as powerful models to identify and characterize susceptibility genes associated with cancer. Furthermore,...

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Identifiers

PMID: 35163487
DOI: 10.3390/ijms23031563
PMCID: PMC8835983

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