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Article

Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media

28 Jan 2022

Abstract excerpt

Otitis media (OM) is a pervasive disease that involves hearing loss and severe complications. In our previous study, we successfully established a mouse model of human OM using Tlr2tm1Kir (TLR2–/–) mice with middle ear (ME) inoculation of streptococcal peptidoglycan-polysaccharide (PGPS). In this study, we found that hearing loss and OM infections in OM mice were significantly alleviated after treatment with...

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PMID: 35153674
DOI: 10.3389/fncel.2021.753369

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