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Article

Generation of an induced pluripotent stem cell line BIOi002-A from a patient with autosomal dominant optic atrophy.

Stem cell research - 1 May 2021

Zhang Xiao-Hui, Xie Yue, Xu Ke, Li Yang

Abstract excerpt

Mutations of the OPA1 gene are responsible for over 70% of autosomal dominant optic atrophy patients. Peripheral blood mononuclear cells (PBMCs) were isolated from a 27-year-old patient with heterozygous c.2708_2711delTTAG mutation in the OPA1 gene. PBMCs were reprogrammed into induced pluripotent stem cell (iPSC) line with episomal plasmids encoding hOCT4, hSOX2, hNANOG, hLIN28, hKLF4 and hL-MYC. The established...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33752025
DOI: 10.1016/j.scr.2021.102278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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