Article
Association of Titin Variations With Late-Onset Dilated Cardiomyopathy.
JAMA cardiology - 1 Apr 2022
Cannatà Antonio, Merlo Marco, Dal Ferro Matteo, Barbati Giulia, Manca Paolo, Paldino Alessia, Graw Sharon, Gigli Marta, Stolfo Davide, Johnson Renee, Roy Darius, Tharratt Kevin, Bromage Daniel I, Jirikowic Jean, Abbate Antonio, Goodwin Allison, Rao Krishnasree, Marawan Amr, Carr-White Gerry, Robert Leema, Parikh Victoria, Ashley Euan, McDonagh Theresa, Lakdawala Neal K, Fatkin Diane, Taylor Matthew R G, Mestroni Luisa, Sinagra Gianfranco
Abstract excerpt
IMPORTANCE: Dilated cardiomyopathy (DCM) is frequently caused by genetic factors. Studies identifying deleterious rare variants have predominantly focused on early-onset cases, and little is known about the genetic underpinnings of the growing numbers of patients with DCM who are diagnosed when they are older than 60 years (ie, late-onset DCM). OBJECTIVE: To investigate the prevalence, type, and prognostic impact...
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