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Article

Quantifying cumulative phenotypic and genomic evidence for procedural generation of metabolic network reconstructions.

PLoS computational biology - 1 Feb 2022

Moutinho Thomas J, Neubert Benjamin C, Jenior Matthew L, Papin Jason A

Abstract excerpt

Genome-scale metabolic network reconstructions (GENREs) are valuable tools for understanding microbial metabolism. The process of automatically generating GENREs includes identifying metabolic reactions supported by sufficient genomic evidence to generate a draft metabolic network. The draft GENRE is then gapfilled with additional reactions in order to recapitulate specific growth phenotypes as indicated with...

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PMID: 35130271
DOI: 10.1371/journal.pcbi.1009341
PMCID: PMC8853471

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