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Article

Deep phenotyping of Alzheimer's disease leveraging electronic medical records identifies sex-specific clinical associations.

Nature communications - 3 Feb 2022

Tang Alice S, Oskotsky Tomiko, Havaldar Shreyas, Mantyh William G, Bicak Mesude, Solsberg Caroline Warly, Woldemariam Sarah, Zeng Billy, Hu Zicheng, Oskotsky Boris, Dubal Dena, Allen Isabel E, Glicksberg Benjamin S, Sirota Marina

Abstract excerpt

Alzheimer's Disease (AD) is a neurodegenerative disorder that is still not fully understood. Sex modifies AD vulnerability, but the reasons for this are largely unknown. We utilize two independent electronic medical record (EMR) systems across 44,288 patients to perform deep clinical phenotyping and network analysis to gain insight into clinical characteristics and sex-specific clinical associations in AD....

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Identifiers

PMID: 35115528
DOI: 10.1038/s41467-022-28273-0
PMCID: PMC8814236

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