Article
Frequent Suboptimal Thermocycler Ramp Rate Usage Negatively Impacts GenoType MTBDRsl VER 2.0 Performance for Second-Line Drug-Resistant Tuberculosis Diagnosis.
The Journal of molecular diagnostics : JMD - 1 May 2022
Derendinger Brigitta, de Vos Margaretha, Pillay Samantha, Venter Rouxjeane, Metcalfe John, Ghebrekristos Yonas, Minnies Stephanie, Dolby Tania, Beylis Natalie, Warren Robin, Theron Grant
Abstract excerpt
Strengthening second-line drug-resistant tuberculosis (TB) detection is a priority. GenoType MTBDRplus VER 2.0 performance is reduced with non-recommended ramp rate usage (temperature change speed between PCR cycles); however, ramp rate's effect on GenoType MTBDRsl VER 2.0 (MTBDRsl) performance, is unknown. Fifty-two Xpert MTB/RIF Ultra-positive rifampicin-resistant smear-negative sputa and a Mycobacterium...
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