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Article

Leigh Syndrome: A Study of 209 Patients at the Beijing Children's Hospital.

Annals of neurology - 1 Apr 2022

Stenton Sarah L, Zou Ying, Cheng Hua, Liu Zhimei, Wang Junling, Shen Danmin, Jin Hong, Ding Changhong, Tang Xiaolu, Sun Suzhen, Han Hong, Ma Yanli, Zhang Weihua, Jin Ruifeng, Wang Hua, Sun Dan, Lv Jun Lan, Prokisch Holger, Fang Fang

Abstract excerpt

OBJECTIVE: Leigh syndrome (LS) is a heterogeneous neurodegenerative disease and the most frequent pediatric manifestation of mitochondrial disease. In the largest patient collection to date, this study aimed to provide new insights into the clinical and genetic spectrum of LS, defect-specific associations, and predictors of disease course and survival. METHODS: Clinical, metabolic, neuroimaging, onset, and...

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PMID: 35094435
DOI: 10.1002/ana.26313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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