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Leishmania RNA virus-1 is similarly detected among metastatic and non-metastatic phenotypes in a prospective cohort of American Tegumentary Leishmaniasis.

PLoS neglected tropical diseases - 1 Jan 2022

Valencia Braulio Mark, Lau Rachel, Kariyawasam Ruwandi, Jara Marlene, Ramos Ana Pilar, Chantry Mathilde, Lana Justin T, Boggild Andrea K, Llanos-Cuentas Alejandro

Abstract excerpt

American Tegumentary Leishmaniasis (ATL) is an endemic and neglected disease of South America. Here, mucosal leishmaniasis (ML) disproportionately affects up to 20% of subjects with current or previous localised cutaneous leishmaniasis (LCL). Preclinical and clinical reports have implicated the Leishmania RNA virus-1 (LRV1) as a possible determinant of progression to ML and other severe manifestations such as...

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PMID: 35089930
DOI: 10.1371/journal.pntd.0010162
PMCID: PMC8827429

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