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Unraveling the genetic diversity and phylogeny of Leishmania RNA virus 1 strains of infected Leishmania isolates circulating in French Guiana.

PLoS neglected tropical diseases - 1 Jul 2017

Tirera Sourakhata, Ginouves Marine, Donato Damien, Caballero Ignacio S, Bouchier Christiane, Lavergne Anne, Bourreau Eliane, Mosnier Emilie, Vantilcke Vincent, Couppié Pierre, Prevot Ghislaine, Lacoste Vincent

Abstract excerpt

INTRODUCTION: Leishmania RNA virus type 1 (LRV1) is an endosymbiont of some Leishmania (Vianna) species in South America. Presence of LRV1 in parasites exacerbates disease severity in animal models and humans, related to a disproportioned innate immune response, and is correlated with drug treatment failures in humans. Although the virus was identified decades ago, its genomic diversity has been overlooked until...

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Cluster Analysis
French Guiana
Genome, Viral
Leishmania
Leishmaniasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Alignment

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PMID: 28715422
DOI: 10.1371/journal.pntd.0005764
PMCID: PMC5531682

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