Article
Aquagenic wrinkling of the palms in cystic fibrosis patients treated with ivacaftor.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2022
Jacobi Eyal, Solomon Melinda, Avolio Julie, Shaw Michelle, Gonska Tanja, Ratjen Felix, Grasemann Hartmut
Abstract excerpt
Aquagenic wrinkling of palms (AWP) in cystic fibrosis (CF) patients and common CFTR mutations is recognized as a frequent symptom of the disease. The long-term effect of CFTR targeting therapy on AWP has not been studied. AWP was monitored in 16 CF patients (8 children and 8 adults) before and for 6 months after initiation of ivacaftor therapy. Thirteen (81.3%) patients had at least mild and 8/16 (50%)...
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