Article
Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis.
Nutrients - 15 Jan 2022
Usategui-Martín Ricardo, De Luis-Román Daniel-Antonio, Fernández-Gómez José María, Ruiz-Mambrilla Marta, Pérez-Castrillón José-Luis
Abstract excerpt
The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs1544410), Taql...
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