Article
The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain.
Signal transduction and targeted therapy - 19 Jan 2022
Wu Jiajing, Nie Jianhui, Zhang Li, Song Hao, An Yimeng, Liang Ziteng, Yang Jing, Ding Ruxia, Liu Shuo, Li Qianqian, Li Tao, Cui Zhimin, Zhang Mengyi, He Peng, Wang Youchun, Qu Xiaowang, Hu Zhongyu, Wang Qihui, Huang Weijin
Abstract excerpt
Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment. To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine, the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared. The neutralization activities of Alpha, Beta and Gamma variants' spike protein-immunized sera...
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