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Article

Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2022

Subbiah V, Kreitman R J, Wainberg Z A, Cho J Y, Schellens J H M, Soria J C, Wen P Y, Zielinski C C, Cabanillas M E, Boran A, Ilankumaran P, Burgess P, Romero Salas T, Keam B

Abstract excerpt

BACKGROUND: Combined therapy with dabrafenib plus trametinib was approved in several countries for treatment of BRAF V600E-mutant anaplastic thyroid cancer (ATC) based on an earlier interim analysis of 23 response-assessable patients in the ATC cohort of the phase II Rare Oncology Agnostic Research (ROAR) basket study. We report an updated analysis describing the efficacy and safety of dabrafenib plus trametinib...

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Identifiers

PMID: 35026411
DOI: 10.1016/j.annonc.2021.12.014
PMCID: PMC9338780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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