Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis

28 Dec 2021

Abstract excerpt

The Toll-like receptor (TLR) family signature has been linked to the etiopathology of atopic dermatitis (AD), a chronic inflammatory skin disease associated with skin barrier dysfunction and immune system imbalance. We aimed to investigate whether osthole (a plant-derived compound) can inhibit the genetic profile of key genes associated with TLR2 signaling (TIRAP, MyD88, IRAK1, TRAF6, IκBα, NFκB) after...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allergic Rhinitis and Sensitization
Share to Asthma and respiratory diseases
Share to Dermatology and Skin Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35011650
DOI: 10.3390/cells11010088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic DermatitisPMID 35011650Read ↗

Toll-Like Receptors: Role in Dermatological DiseaseSemantic proximity Read ↗

Proteomic analysis of the regulation of quercetin on TNF-α/IFN-γ- induced hyperactivation of keratinocytesSemantic proximity Read ↗

Polyphenols and Cannabidiol Modulate Transcriptional Regulation of Th1/Th2 Inflammatory Genes Related to Canine Atopic DermatitisSemantic proximity Read ↗

Molecular Mechanisms of Luteolin Against Atopic Dermatitis Based on Network Pharmacology and in vivo Experimental ValidationSemantic proximity Read ↗

Investigating the Epidermal Anti-inflammatory Properties of Paris Polyphylla through Network Pharmacology and Experimental StudiesSemantic proximity Read ↗

Association of TLR2 and TLR9 gene polymorphisms with atopic dermatitis: a systematic review and meta-analysis with trial sequential analysis.Semantic proximity Read ↗

New insights in the pathogenesis of atopic dermatitis.Semantic proximity Read ↗

Allicin Ameliorates IMQ-induced psoriasis-like Skin Inflammation Via Disturbing the Interaction of Keratinocytes with IL-17ASemantic proximity Read ↗

Network pharmacology and in silico analysis reveal Kochiae Fructus as a potential therapeutic against atopic dermatitis through immunomodulatory pathway interactionsSemantic proximity Read ↗

Compound Traditional Chinese Medicine Dermatitis Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules in ADSemantic proximity Read ↗

TLR3 in Chronic Human Itch: A Keratinocyte-Associated Mechanism of Peripheral Itch SensitizationSemantic proximity Read ↗

Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-κB signaling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.