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Article

Efficacy of levetiracetam in STXBP1 encephalopathy with different phenotypic and genetic spectra.

Seizure - 1 Feb 2022

Wang Qiu-Hong, Cao Jia-Jie, Wang Yang-Yang, Zhang Meng-Na, Liu Li-Ying, Wang Jing, Lu Qian, He Wen, Shen Yan-Wen, Chen Hui-Min, Luo Xiao-Mei, Chen Qian, Zou Li-Ping

Abstract excerpt

OBJECTIVE: Syntaxin binding protein 1 (STXBP1) plays an important role in the release of synaptic vesicles. STXBP1-related encephalopathy is a brain dysfunction caused by STXBP1 variation. Levetiracetam (LEV) exerts antiepileptic effects by binding to synaptic vesicle protein 2A (SV2A). This study aimed to analyze the prognosis of LEV treatment of STXBP1 encephalopathy (STXBP1-E) and the correlation among...

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PMID: 35007884
DOI: 10.1016/j.seizure.2021.12.006

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