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Gene expression profiling and pathway analysis in head and neck squamous cell carcinoma: focus on disulfidptosis

18 Apr 2025

Abstract excerpt

This study aimed to characterize the prognostic and therapeutic implications of disulfidptosis-related genes (DRGs) in head and neck squamous cell carcinoma (HNSCC). Using multi-omics data from the Cancer Genome Atlas (TCGA) (n = 500) and Gene Expression Omnibus (GEO) cohorts (n = 270), we performed unsupervised consensus clustering, functional enrichment, immune deconvolution, and survival analyses to identify...

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PMID: 40246729
DOI: 10.1007/s12672-025-02344-2

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