A quantitative framework reveals traditional laboratory growth is a highly accurate model of human oral infection

Abstract excerpt

Significance Most microbial knowledge comes from experiments in laboratory models, despite the assumption that these artificial systems alter microbial physiology relative the native environment. We tested this assumption for an oral pathogen, Porphyromonas gingivalis , using 93 metatranscriptomes from periodontally healthy and diseased patients and 122 transcriptomes from experimental models. We discovered that...

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