Longitudinal host-microbiome dynamics of metatranscription identify hallmarks of progression in periodontitis

Abstract excerpt

BACKGROUND: In periodontitis, the interplay between the host and microbiome generates a self-perpetuating cycle of inflammation of tooth-supporting tissues, potentially leading to tooth loss. Despite increasing knowledge of the phylogenetic compositional changes of the periodontal microbiome, the current understanding of in situ activities of the oral microbiome and the interactions among community members and...

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