Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial.

doi:10.1016/S2213-2600(21)00454-9

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Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial.

The Lancet. Respiratory medicine - 1 Mar 2022

Sutharsan Sivagurunathan, McKone Edward F, Downey Damian G, Duckers Jamie, MacGregor Gordon, Tullis Elizabeth, Van Braeckel Eva, Wainwright Claire E, Watson Danie, Ahluwalia Neil, Bruinsma Bote G, Harris Christopher, Lam Anna P, Lou Yiyue, Moskowitz Samuel M, Tian Simon, Yuan Jason, Waltz David, Mall Marcus A

Abstract excerpt

BACKGROUND: Elexacaftor plus tezacaftor plus ivacaftor is a triple-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator regimen shown to be generally safe and efficacious in people with cystic fibrosis aged 12 years or older with at least one F508del-CFTR allele. We aimed to assess the magnitude and durability of the clinical effects of this triple combination regimen in people with...

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PMID: 34942085
DOI: 10.1016/S2213-2600(21)00454-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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