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Article

The pediatric common variable immunodeficiency - from genetics to therapy: a review.

European journal of pediatrics - 1 Apr 2022

Szczawinska-Poplonyk Aleksandra, Schwartzmann Eyal, Bukowska-Olech Ewelina, Biernat Michal, Gattner Stanislaw, Korobacz Tomasz, Nowicki Filip, Wiczuk-Wiczewska Monika

Abstract excerpt

Common variable immunodeficiency (CVID) is the most prevalent antibody deficiency, characterized by remarkable genetic, immunological, and clinical heterogeneity. The diagnosis of pediatric CVID is challenging due to the immaturity of the immune response and sustained actively developing antibody affinity to antigens and immunological memory that may overlap with the inborn error of immunity. Significant progress...

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Identifiers

PMID: 34939152
DOI: 10.1007/s00431-021-04287-6
PMCID: PMC8964589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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