Novel Functional, Health, and Genetic Determinants of Cognitive Terminal Decline: Kuakini Honolulu Heart Program/Honolulu-Asia Aging Study.

doi:10.1093/gerona/glab327

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Article

Novel Functional, Health, and Genetic Determinants of Cognitive Terminal Decline: Kuakini Honolulu Heart Program/Honolulu-Asia Aging Study.

The journals of gerontology. Series A, Biological sciences and medical sciences - 12 Aug 2022

Margrett Jennifer A, Schofield Thomas, Martin Peter, Poon Leonard W, Masaki Kamal, Donlon Timothy A, Kallianpur Kalpana J, Willcox Bradley J

Abstract excerpt

To investigate interindividual differences in cognitive terminal decline and identify determinants including functional, health, and genetic risk and protective factors, data from the Honolulu Heart Program/Honolulu-Asia Aging Study, a prospective cohort study of Japanese American men, were analyzed. The sample was recruited in 1965-1968 (ages 45-68 years). Longitudinal performance of cognitive abilities and...

Topics

Aged
Aged, 80 and over
Aging
Alleles
Apolipoprotein E2
Apolipoprotein E4
Apolipoproteins E
Asian
Cognition
Cognitive Dysfunction
Forkhead Box Protein O3
Hawaii
Humans

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PMID: 34918073
DOI: 10.1093/gerona/glab327
PMCID: PMC9373950

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