Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Network-based identification of miRNAs and transcription factors and in silico drug screening targeting δ-secretase involved in Alzheimer's disease

29 Nov 2021

Abstract excerpt

Background System medicine approaches have played a pivotal role in identifying novel disease networks especially in miRNA research. It is no wonder that miRNAs are implicated in multiple clinical conditions, allowing us to establish the hubs and nodes for network models of Alzheimer's Disease (AD). AD is an age-related, progressive, irreversible, and multifactorial neurodegenerative disorder characterized by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Biological Research and Disease Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34917801
DOI: 10.1016/j.heliyon.2021.e08502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Network-based identification of miRNAs and transcription factors and in silico drug screening targeting δ-secretase involved in Alzheimer's diseasePMID 34917801Read ↗

Key Regulators of Alzheimer’s Disease: Network Biology and In-Silico Analysis with AChE and Glutamate InhibitorsSemantic proximity Read ↗

MicroRNA-Target Interaction Regulatory Network in Alzheimer’s DiseaseSemantic proximity Read ↗

Identification of miRNA–mRNA Pairs in the Alzheimer’s Disease Expression Profile and Explore the Effect of miR-26a-5p/PTGS2 on Amyloid-β Induced Neurotoxicity in Alzheimer’s Disease Cell ModelSemantic proximity Read ↗

Network Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer's Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the Disease.Semantic proximity Read ↗

Key genes and pathways in asparagine metabolism in Alzheimer’s Disease: a bioinformatics approachSemantic proximity Read ↗

Drug Target Prioritization for Alzheimer's Disease Using Protein Interaction Network AnalysisSemantic proximity Read ↗

Network Theoretical Approach to Explore Factors Affecting Signal Propagation and Stability in Dementia’s Protein-Protein Interaction NetworkSemantic proximity Read ↗

Gene expression profiling in cells with enhanced gamma-secretase activity.Semantic proximity Read ↗

Key Molecules and Pathways Underlying Sporadic Amyotrophic Lateral Sclerosis: Integrated Analysis on Gene Expression Profiles of Motor NeuronsSemantic proximity Read ↗

Pur-alpha participates in the progression of Alzheimer's disease through direct and indirect waysSemantic proximity Read ↗

NeuroDNet - an open source platform for constructing and analyzing neurodegenerative disease networksSemantic proximity Read ↗

Ingenuity pathway analysis of α-synuclein predicts potential signaling pathways, network molecules, biological functions, and its role in neurological diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.