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Article

A novel genetic variant potentially altering the expression of MANBA in the cerebellum associated with attention deficit hyperactivity disorder in Han Chinese children.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Sept 2022

Chen Xinzhen, Yao Ting, Cai Jinliang, Zhang Qi, Li Shanyawen, Li Huiru, Fu Xihang, Wu Jing

Abstract excerpt

OBJECTIVES: To obtain additional insight into the genetic factors of attention deficit hyperactivity disorder (ADHD). METHODS: First, we performed a transcriptome-wide association study (TWAS) integrating human cerebellum-specific variant-expression/splicing correlations to identify ADHD susceptibility genes. Then, the associations between expression/splicing quantitative trait loci (eQTLs/sQTLs) of the...

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PMID: 34870556
DOI: 10.1080/15622975.2021.2014248

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