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Article

Colorectal paragangliomas with immunohistochemical deficiency of succinate dehydrogenase subunit B.

Endocrine journal - 30 May 2022

Kimura Noriko, Ishikawa Misawo, Shigematsu Kazuto

Abstract excerpt

Recent progress in paraganglioma (PGL) revealed genotype-phenotype relationship, especially succinate dehydrogenase complex subunit B (SDHB) gene mutation-related to the extra-adrenal origin and metastasis. SDHB-immunohistochemistry can detect all types of SDH-subunit mutations, and is a useful tool to detect SDH-mutation tumors. PGLs usually occur along with sympathetic, and parasympathetic chains, however,...

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PMID: 34853215
DOI: 10.1507/endocrj.EJ21-0630

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