Immune reactivity and host modulatory roles of two novel Haemonchus contortus cathepsin B-like proteases

Abstract excerpt

Abstract Background Haemonchus contortusis a blood-feeding, gastrointestinal nematode (GIN) that causes significant economic losses to the small ruminant industry worldwide. Despite extensive efforts, our understanding of the molecular mechanisms used by GIN to evade host immune responses is limited. Cathepsin B-like proteins (CBPs) are members of the cysteine protease family and are involved in parasite invasion...

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