Slow Recovery from Inbreeding Depression Generated by the Complex Genetic Architecture of Segregating Deleterious Mutations.

doi:10.1093/molbev/msab330

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Article

Slow Recovery from Inbreeding Depression Generated by the Complex Genetic Architecture of Segregating Deleterious Mutations.

Molecular biology and evolution - 7 Jan 2022

Adams Paula E, Crist Anna B, Young Ellen M, Willis John H, Phillips Patrick C, Fierst Janna L

Abstract excerpt

The deleterious effects of inbreeding have been of extreme importance to evolutionary biology, but it has been difficult to characterize the complex interactions between genetic constraints and selection that lead to fitness loss and recovery after inbreeding. Haploid organisms and selfing organisms like the nematode Caenorhabditis elegans are capable of rapid recovery from the fixation of novel deleterious...

Topics

Alleles
Animals
Caenorhabditis elegans
Inbreeding
Inbreeding Depression
Male
Mutation

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PMID: 34791426
DOI: 10.1093/molbev/msab330
PMCID: PMC8789292

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