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Article

SARS-CoV-2 variants with T135I nucleocapsid mutations may affect antigen test performance.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Jan 2022

Jian Ming-Jr, Chung Hsing-Yi, Chang Chih-Kai, Lin Jung-Chung, Yeh Kuo-Ming, Chen Chien-Wen, Lin De-Yu, Chang Feng-Yee, Hung Kuo-Sheng, Perng Cherng-Lih, Shang Hung-Sheng

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic. Diagnostic testing for SARS-CoV-2 has continuously been challenged due to several variants with diverse spike (S) and nucleocapsid (N) protein mutations []. SARS-CoV-2 variant proliferation potentially affects N protein-targeted rapid antigen testing. In this study, rapid antigen and reverse transcription PCR (RT-PCR) tests were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34758391
DOI: 10.1016/j.ijid.2021.11.006
PMCID: PMC8572148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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