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Article

Leveraging Genetic Data to Elucidate the Relationship Between COVID-19 and Ischemic Stroke.

Journal of the American Heart Association - 16 Nov 2021

Zuber Verena, Cameron Alan, Myserlis Evangelos P, Bottolo Leonardo, Fernandez-Cadenas Israel, Burgess Stephen, Anderson Christopher D, Dawson Jesse, Gill Dipender

Abstract excerpt

Background The relationship between COVID-19 and ischemic stroke is poorly understood due to potential unmeasured confounding and reverse causation. We aimed to leverage genetic data to triangulate reported associations. Methods and Results Analyses primarily focused on critical COVID-19, defined as hospitalization with COVID-19 requiring respiratory support or resulting in death. Cross-trait linkage...

Topics

Body Mass Index
Brain Ischemia
C-Reactive Protein
COVID-19
Genome-Wide Association Study
Humans
Inflammation
Ischemic Stroke
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 34755518
DOI: 10.1161/JAHA.121.022433
PMCID: PMC8751930

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