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Real-time PCR-based detection of the Alu-mediated deletion of FUT2 (sedel2).

Legal medicine (Tokyo, Japan) - 1 Feb 2022

Soejima Mikiko, Koda Yoshiro

Abstract excerpt

Secretor status of the ABH(O) histoblood group antigens is regulated by secretor type α(1,2)fucosyltransferase encoded by FUT2. The sedel2 allele is a complete deletion of the FUT2 coding region generated by Alu-mediated homologous recombination. This deletion seems to be exclusively encountered in certain Oceanian populations. From the perspective of forensic science, sedel2 is considered to be one of ancestry...

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PMID: 34736142
DOI: 10.1016/j.legalmed.2021.101986

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