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Article

Genetic variants in histone modification regions are associated with the prognosis of lung adenocarcinoma.

Scientific reports - 2 Nov 2021

Kang Hyo-Gyoung, Lee Yong Hoon, Lee Shin Yup, Choi Jin Eun, Do Sook Kyung, Hong Mi Jeong, Lee Jang Hyuck, Jeong Ji Yun, Do Young Woo, Lee Eung Bae, Shin Kyung Min, Lee Won Kee, Choi Sun Ha, Seo Hye Won, Yoo Seung Soo, Lee Jaehee, Cha Seung Ick, Kim Chang Ho, Cho Sukki, Jheon Sanghoon, Park Jae Yong

Abstract excerpt

We investigated the association between genetic variants in the histone modification regions and the prognosis of lung adenocarcinoma after curative surgery. Potentially functional SNPs were selected using integrated analysis of ChIP-seq and RNA-seq. The SNPs were analyzed in a discovery set (n = 166) and a validation set (n = 238). The associations of the SNPs with overall survival (OS) and disease-free survival...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34728688
DOI: 10.1038/s41598-021-00909-z
PMCID: PMC8563968

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