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Article

Hepatitis C Virus-Induced Exosomal MicroRNAs and Toll-Like Receptor 7 Polymorphism Regulate B-Cell Activating Factor.

mBio - 21 Dec 2021

Liao Tsai-Ling, Chen Yi-Ming, Hsieh Shie-Liang, Tang Kuo-Tung, Chen Der-Yuan, Yang Ying-Ying, Liu Hung-Jen, Yang Sheng-Shun

Abstract excerpt

There are large gaps in understanding the molecular machinery accounting for the association of hepatitis C virus (HCV) infection with autoimmunity. Mixed cryoglobulinemia (MC) is the most common HCV-associated extrahepatic manifestation, which is characterized by B-cell lymphoproliferation and autoantibody production. B-cell activating factor (BAFF) is a member of the tumor necrosis factor family and plays an...

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PMID: 34724826
DOI: 10.1128/mBio.02764-21
PMCID: PMC8561394

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