Article
X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes.
PLoS neglected tropical diseases - 1 Oct 2021
Mattick John, Libro Silvia, Bromley Robin, Chaicumpa Wanpen, Chung Matthew, Cook Darren, Khan Mohammad Behram, Kumar Nikhil, Lau Yee-Ling, Misra-Bhattacharya Shailja, Rao Ramakrishna, Sadzewicz Lisa, Saeung Atiporn, Shahab Mohd, Sparklin Benjamin C, Steven Andrew, Turner Joseph D, Tallon Luke J, Taylor Mark J, Moorhead Andrew R, Michalski Michelle, Foster Jeremy M, Dunning Hotopp Julie C
Abstract excerpt
The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping in order to identify single nucleotide variants and insertions/deletions. In natural and laboratory Brugia populations, there is a lack of sequence diversity on chromosome X relative to the autosomes (πX/πA = 0.2), which is lower than the expected (πX/πA =...
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