Article
On-Demand Patient-Specific Phenotype-to-Genotype Ebola Virus Characterization.
Viruses - 6 Oct 2021
Beitzel Brett F, Radoshitzky Sheli R, Di Paola Nicholas, Brannan Jennifer M, Kimmel David, Caviness Katie, Soloveva Veronica, Yu Shuiqing, Postnikova Elena N, Finch Courtney L, Liu Hu, Prugar Laura, Bakken Russell, Dye John M, Kugelman Jeffrey R, Cunningham James M, Sanchez-Lockhart Mariano, Kuhn Jens H, Palacios Gustavo
Abstract excerpt
Biosafety, biosecurity, logistical, political, and technical considerations can delay or prevent the wide dissemination of source material containing viable virus from the geographic origin of an outbreak to laboratories involved in developing medical countermeasures (MCMs). However, once virus genome sequence information is available from clinical samples, reverse-genetics systems can be used to generate virus...
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