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MicroRNA profiling in the bursae of Marek's disease virus-infected resistant and susceptible chicken lines.

Genomics - 1 May 2020

Heidari Mohammad, Zhang Lei, Zhang Huanmin

Abstract excerpt

Marek's disease (MD) is a lymphoproliferative disease of domestic chickens caused by a cell-associated oncogenic alpha-herpesvirus, Marek's disease virus (MDV). Clinical signs of MD include bursal/thymic atrophy, neurologic disorders, and T cell lymphomas. MiRNAs play key roles in regulation of gene expression by targeting translational suppression or mRNA degradation. MDV encodes miRNAs that are associated with...

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PMID: 32059995
DOI: 10.1016/j.ygeno.2020.02.009

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