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Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses

21 Oct 2021

Abstract excerpt

There is a persistent bias toward higher prevalence and increased severity of coronavirus disease 2019 (COVID-19) in males. Underlying mechanisms accounting for this sex difference remain incompletely understood. Interferon responses have been implicated as a modulator of COVID-19 disease in adults and play a key role in the placental antiviral response. Moreover, the interferon response has been shown to alter...

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PMID: 34664987
DOI: 10.1126/scitranslmed.abi7428

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