Polymorphism in cytochrome P4502A6 reduces the risk to head and neck cancer and modifies the treatment outcome.

doi:10.1002/em.22466

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Polymorphism in cytochrome P4502A6 reduces the risk to head and neck cancer and modifies the treatment outcome.

Environmental and molecular mutagenesis - 1 Nov 2021

Yadav Vinay Kumar, Katiyar Tridiv, Ruwali Munindra, Yadav Sanjay, Singh Sudhir, Hadi Rahat, Bhatt Madan Lal Brahma, Parmar Devendra

Abstract excerpt

The present case-control study consisting of 1300 cases of head and neck squamous cell carcinoma (HNSCC) and the equal number of controls aimed to investigate the association of functionally important polymorphisms in cytochrome P4502A6 (CYP2A6*1B, CYP2A6*4C, CYP2A6*9-rs28399433) with HNSCC and the treatment response in cases receiving a combination of chemotherapy/radiotherapy (CT/RT). A significant decrease in...

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PMID: 34655463
DOI: 10.1002/em.22466

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