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Article

Simulation of the Interactions of Arginine with Wild-Type GALT Enzyme and the Classic Galactosemia-Related Mutant p.Q188R by a Computational Approach.

Molecules (Basel, Switzerland) - 7 Oct 2021

Verdino Anna, D'Urso Gaetano, Tammone Carmen, Scafuri Bernardina, Catapano Lucrezia, Marabotti Anna

Abstract excerpt

Classic galactosemia is an inborn error of metabolism associated with mutations that impair the activity and the stability of galactose-1-phosphate uridylyltransferase (GALT), catalyzing the third step in galactose metabolism. To date, no treatments (including dietary galactose deprivation) are able to prevent or alleviate the long-term complications affecting galactosemic patients. Evidence that arginine is able...

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Identifiers

PMID: 34641605
DOI: 10.3390/molecules26196061
PMCID: PMC8513022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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